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Recent discovery "Cosmc Controls B Cell Homing" by Zeng et al.

August 12, 2020

Everyone has heard of lymph nodes, the place where our white blood cells (lymphocytes) move into, out of, and around our bodies; and we all know that lymphocytes are important cells for immune health and for fighting disease.   But what do the lymphocytes need in order to do the moving around?  A breakthrough discovery in how lymphocytes migrate into lymph nodes is reported in a paper appearing in Nature Communications from the laboratory of Richard D. Cummings at Beth Israel Deaconess Medical Center and Harvard Medical School; the first author on the paper is Junwei Zeng...

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Recent Preprint work - "SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors"

August 12, 2020

How many ways can the SARS-CoV-2 virus, which is the cause of our current COVID-19 pandemic, interact with our cells and tissues? At the NCFG in the Department of Surgery at the Beth Israel Deaconess Medical Center and Harvard Medical School, we have recently discovered that the spike glycoprotein of SARS-CoV-2 has many attached carbohydrates (glycans) that can bind to a variety of carbohydrate-binding C-type lectin receptors (CLRs) that are on our macrophages, dendritic cells and other types of cells.  Furthermore, the amino acids carrying many of the attached carbohydrates were...

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