News

Identification and Characterization of Circulating Immune Complexes in IgA Nephropathy

October 29, 2022

Co-First Authors: Yasuyuki Matsumoto and Rajindra P Aryal

Senior/Corresponding Author: Richard D Cummings, Professor, Dept. of Surgery, BIDMC/Harvard Medical School

Published in Science Advances, October 28, 2022

A breakthrough in our understanding the human disease called IgA Nephropathy, has just been published in Science Advances.  IgA Nephropathy is one of the most common causes of kidney diseases...

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4th Edition of the Essentials of Glycobiology Book is now released

May 10, 2022

The 4th Edition of Essentials of Glycobiology book is now available open access for anyone to read. The texbook is a great resource for beginners in glycoscience and a wonderful reference for experts as well.

The soft copy of the book is available online for free. You can access it by visiting: https://ncbi.nlm.nih.gov/books/NBK579918/

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Akul Mehta from the NCFG presents at the European Glycoscience Community Webinar Series

May 5, 2022

Dr. Akul Mehta from the NCFG presented a talk titled "From Parallel Synthesis of Glycopeptides, to Glycan Arrays and Glycan Informatics" at the European Glycoscience Community Webinar Series, where he discussed GlycoSPOT synthesis method for parallel synthesis of glycopeptides and the various bioinformatics tools...

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Massachusetts Life Sciences Center announces capital funding to support innovation infrastructure- HMS Center for Glycoscience, NCFG, Glycomics Core recipients of funds

March 4, 2022

Massachusetts Life Sciences Center awards HMS Center for Glycoscience, the NCFG and the Glycomics Core at BIDMC $1.4 million for project titled " Innovative Glycoscience for Diagnostic and Therapeutic Advances". 

“This incredible support by the Massachusetts Life Sciences Center is vital to the development of glycosciences and medical advances in this area,” said Richard D. Cummings, PhD, Director of the HMS Center for Glycoscience at BIDMC. “The key resources to be provided by the funds will be transformative to not only our team but will aid researchers and companies...

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An X-linked Gene Associated with Autoimmune Disorders

October 6, 2021

An exciting new discovery from researchers at Harvard Medical School has provided new insight into the possible cause of some autoimmune disorders. Autoimmune diseases are among the most common afflictions of humans, yet their root causes are not known.  Most arise spontaneously or sporadically in people without a clear genetic linkage or heritability.  Diseases such as systemic lupus erythematosus are found primarily in women with an approximate 9:1 female:male ratio.  The laboratory of Richard D. Cummings, Ph.D. and Junwei Zeng, Ph.D. in the Department of Surgery at Beth...

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Quanta Magazine - Researchers Read the Sugary ‘Language’ on Cell Surfaces

June 14, 2021

Glycans, the complex sugars that stud cellular surfaces, are like a language that life uses to mediate vital interactions. Researchers are learning how to read their meaning.

Dr. Richard Cummings from the NCFG talks about the role of glycomolecules and the challenges in the field.

Read the full story at Quanta Magazine.

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Recent discovery "Cosmc Controls B Cell Homing" by Zeng et al.

August 12, 2020

Everyone has heard of lymph nodes, the place where our white blood cells (lymphocytes) move into, out of, and around our bodies; and we all know that lymphocytes are important cells for immune health and for fighting disease.   But what do the lymphocytes need in order to do the moving around?  A breakthrough discovery in how lymphocytes migrate into lymph nodes is reported in a paper appearing in Nature Communications from the laboratory of Richard D. Cummings at Beth Israel Deaconess Medical Center and Harvard Medical School; the first author on the paper is Junwei Zeng...

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Recent Preprint work - "SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors"

August 12, 2020

How many ways can the SARS-CoV-2 virus, which is the cause of our current COVID-19 pandemic, interact with our cells and tissues? At the NCFG in the Department of Surgery at the Beth Israel Deaconess Medical Center and Harvard Medical School, we have recently discovered that the spike glycoprotein of SARS-CoV-2 has many attached carbohydrates (glycans) that can bind to a variety of carbohydrate-binding C-type lectin receptors (CLRs) that are on our macrophages, dendritic cells and other types of cells.  Furthermore, the amino acids carrying many of the attached carbohydrates were...

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A new technique to produce glycopeptide libraries - GlycoSPOT synthesis

July 1, 2020

Recently we published in Cell Chemical Biology a method to produce glycopeptide libraries in small scale titled: "Parallel Glyco-SPOT Synthesis of Glycopeptide Libraries", The method utilizes a filter paper as the solid support to build a library of glycopeptides in parallel to produce microgram quantities of peptides. In this paper we show how we created two separate libraries of...

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Invitation to join the Human Glycome Project (HGP)

January 23, 2019

Dear Colleagues,

If your research is addressing the structure and/or function of glycans in humans, we are inviting you to join the Human Glycome Project (HGP).

The Human Glycome Project is an international initiative aimed at understanding structure and function of human glycans. It functions as a consortium of research groups with their own independent funding. The HGP will support individual researchers by sharing resources and experience, as well as coordinating research activities on a global level.

Each Full member of the HGP is expected to be an...

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